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La sociedad MIDELOY se constituyó como una Empresa de Base Tecnológica de la Universidad Complutense de Madrid (UCM) para luego, según normativa UCM, convertirse en una Empresa de Transferencia de Conocimiento Universitario de la UCM. Inscrita en el Registro Mercantil de Madrid MIDELOY se fundó como Sociedad Limitada (SL) cuya escritura de constitución fue en Madrid, el 23 de octubre de 2015.

MIDELOY SL, con CIF B-87400297, tiene como objeto social (A) la Investigación en Ciencias Médicas, 936.2 Epígrafe IAE / 7211 Código CNAE; y (B) Venta Electrónica (665 y 614.1 Epígrafes IAE / 4791 y 4646 Códigos CNAE).

Su cofundador, el Dr. Jose Antonio López Moreno, es el actual director y administrador de MIDELOY SL en virtud del Acta de Titularidad Real y poder notarial otorgada el día 26 de abril de 2022 por D. Adolfo Pries Picardo, Notario del Ilustre Colegio de Madrid.

La trayectoria y experiencia de MIDELOY SL se fundamenta en la actividad científica de los integrantes del grupo de investigación “Psicofarmacología, Genética y Prevención de la Adicción” de la Universidad Complutense de Madrid con número de referencia 940157. Esta actividad científica verificable se inicia en el año 2004. En el siguiente apartado se describen, de manera cronológica, de más recientes a más antiguas, las publicaciones científicas de las que el director del grupo de investigación y director de MIDELOY SL es autor/coautor.

Trabajos Científicos Publicados por el director de MIDELOY SL en la «United States National Library of Medicine»

51: Calleja-Conde J, Echeverry-Alzate V, Bühler KM, Morales-García JÁ, Segovia- Rodríguez L, Durán-González P, Olmos P, de Fonseca FR, Giné E, López-Moreno JA. Dissecting operant alcohol self-administration using saccharin-fading procedure. Neuropsychopharmacol Rep. 2023 Mar;43(1):12-22. doi: 10.1002/npr2.12289. Epub 2023 Feb 2. PMID: 36727594; PMCID: PMC10009421.

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50: Calleja-Conde J, Morales-García JA, Echeverry-Alzate V, Bühler KM, Giné E, López-Moreno JA. Classic psychedelics and alcohol use disorders: A systematic review of human and animal studies. Addict Biol. 2022 Nov;27(6):e13229. doi: 10.1111/adb.13229. PMID: 36301215; PMCID: PMC9541961.

49: Bühler KM, Echeverry-Alzate V, Calleja-Conde J, Durán-González P, Segovia- Rodriguez L, Morales-García JA, Pérez-Wiesner M, Cables-Chozas D, de Fonseca FR, Delgado-Iribarren A, Merino-Amador P, González-Romo F, Giné E, López-Moreno JA. Seroprevalence of anti-SARS-CoV-2 IgG antibodies: relationship with COVID-19 diagnosis, symptoms, smoking, and method of transmission. IJID Reg. 2022 Sep;4:10-16. doi: 10.1016/j.ijregi.2022.05.007. Epub 2022 May 27. PMID: 35720660; PMCID: PMC9137247.

48: Segovia-Rodríguez L, Echeverry-Alzate V, Rincón-Pérez I, Calleja-Conde J, Bühler KM, Giné E, Albert J, Hinojosa JA, Huertas E, Gómez-Gallego F, Bressa C, Rodríguez de Fonseca F, López-Moreno JA. Gut microbiota and voluntary alcohol consumption. Transl Psychiatry. 2022 Apr 7;12(1):146. doi: 10.1038/s41398-022-01920-2. PMID: 35393390; PMCID: PMC8990010.

47: Calleja-Conde J, Echeverry-Alzate V, Bühler KM, Durán-González P, Morales-García JÁ, Segovia-Rodríguez L, Rodríguez de Fonseca F, Giné E, López-Moreno JA. The Immune System through the Lens of Alcohol Intake and Gut Microbiota. Int J Mol Sci. 2021 Jul 13;22(14):7485. doi: 10.3390/ijms22147485. PMID: 34299105; PMCID: PMC8303153.

46: Fyke W, Premoli M, Echeverry Alzate V, López-Moreno JA, Lemaire-Mayo V, Crusio WE, Marsicano G, Wöhr M, Pietropaolo S. Communication and social interaction in the cannabinoid-type 1 receptor null mouse: Implications for autism spectrum disorder. Autism Res. 2021 Sep;14(9):1854-1872. doi: 10.1002/aur.2562. Epub 2021 Jun 26. PMID: 34173729.

45: Morales-Garcia JA, Calleja-Conde J, López-Moreno JA,, Alonso-Gil S, Sanz- SanCristobal M, Riba J, Perez-Castillo A. N,N-dimethyltryptamine compound found in the hallucinogenic tea ayahuasca, regulates adult neurogenesis in vitro and in vivo. Transl Psychiatry. 2020 Sep 28;10(1):331. doi: 10.1038/s41398-020-01011-0. PMID: 32989216; PMCID: PMC7522265.

44: Calleja-Conde J, Fernández-Calle R, Zapico JM, Ramos A, de Pascual-Teresa B, Bühler KM, Echeverry-Alzate V, Giné E, Rodríguez de Fonseca F, López-Moreno JA, Herradón G. Inhibition of Receptor Protein Tyrosine Phosphatase β/ζ Reduces Alcohol Intake in Rats. Alcohol Clin Exp Res. 2020 May;44(5):1037-1045. doi: 10.1111/acer.14321. Epub 2020 Mar 27. PMID: 32154588.

43: Rincón-Pérez I, Echeverry-Alzate V, Sánchez-Carmona AJ, Bühler KM, Hinojosa JA, López-Moreno JA, Albert J. The influence of dopaminergic polymorphisms on selective stopping. Behav Brain Res. 2020 Mar 2;381:112441. doi: 10.1016/j.bbr.2019.112441. Epub 2019 Dec 19. PMID: 31863847.

42: Huertas E, López-Moreno JA, Fernández V, Echeverry-Alzate V, Bühler KM. Associations between experimental substance use, FAAH-gene variations, impulsivity and sensation seeking. Psicothema. 2019 Aug;31(3):239-245. doi: 10.7334/psicothema2019.27. PMID: 31292037.

41: Ruiz-Roso MB, Echeverry-Alzate V, Ruiz-Roso B, Quintela JC, Ballesteros S, Lahera V, de Las Heras N, López-Moreno JA, Martín-Fernández B. Low Phytanic Acid-Concentrated DHA Prevents Cognitive Deficit and Regulates Alzheimer Disease Mediators in an ApoE Mice Experimental Model. Nutrients. 2018 Dec 20;11(1):11. doi: 10.3390/nu11010011. PMID: 30577526; PMCID: PMC6356727.

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40: Echeverry-Alzate V, Bühler KM, Calleja-Conde J, Huertas E, Maldonado R, Rodríguez de Fonseca F, Santiago C, Gómez-Gallego F, Santos A, Giné E, López-Moreno JA,. Adult-onset hypothyroidism increases ethanol consumption. Psychopharmacology (Berl). 2019 Apr;236(4):1187-1197. doi: 10.1007/s00213-018-5123-1. Epub 2018 Nov 23. PMID: 30470859.

39: Alen F, Decara J, Brunori G, You ZB, Bühler KM, López-Moreno JA, Cippitelli A, Pavon FJ, Suárez J, Gardner EL, de la Torre R, Ciccocioppo R, Serrano A, Rodríguez de Fonseca F. PPARα/CB1 receptor dual ligands as a novel therapy for alcohol use disorder: Evaluation of a novel oleic acid conjugate in preclinical rat models. Biochem Pharmacol. 2018 Nov;157:235-243. doi: 10.1016/j.bcp.2018.09.008. Epub 2018 Sep 6. PMID: 30195735.

38: Marco EM, Peñasco S, Hernández MD, Gil A, Borcel E, Moya M, Giné E, López-Moreno JA, Guerri C, López-Gallardo M, Rodríguez de Fonseca F. Long-Term Effects of Intermittent Adolescent Alcohol Exposure in Male and Female Rats. Front Behav Neurosci. 2017 Nov 28;11:233. doi: 10.3389/fnbeh.2017.00233. PMID: 29234279; PMCID: PMC5712378.

37: Roldán M, Echeverry-Alzate V, Bühler KM, Sánchez-Diez IJ, Calleja-Conde J, Olmos P, Boehm SL, Maldonado R, Rodríguez de Fonseca F, Santiago C, Gómez- Gallego F, Giné E, López-Moreno JA. Red Bull® energy drink increases consumption of higher concentrations of alcohol. Addict Biol. 2018 Sep;23(5):1094-1105. doi: 10.1111/adb.12560. Epub 2017 Sep 22. PMID: 28940880.

36: Giné E, Echeverry-Alzate V, López-Moreno JA, Rodriguez de Fonseca F, Perez- Castillo A, Santos A. The CB1 receptor is required for the establishment of the hyperlocomotor phenotype in developmentally-induced hypothyroidism in mice. Neuropharmacology. 2017 Apr;116:132-141. doi: 10.1016/j.neuropharm.2016.12.018. Epub 2016 Dec 23. PMID: 8017790.

35: Pavón FJ, Marco EM, Vázquez M, Sánchez L, Rivera P, Gavito A, Mela V, Alén F, Decara J, Suárez J, Giné E, López-Moreno JA, Chowen J, Rodríguez-de-Fonseca F, Serrano A, Viveros MP. Effects of Adolescent Intermittent Alcohol Exposure on the Expression of Endocannabinoid Signaling-Related Proteins in the Spleen of Young Adult Rats. PLoS One. 2016 Sep 23;11(9):e0163752. doi: 10.1371/journal.pone.0163752. PMID: 27662369; PMCID: PMC5035052.

34: Morales-Garcia JA, Echeverry-Alzate V, Alonso-Gil S, Sanz-SanCristobal M, López-Moreno JA,, Gil C, Martinez A, Santos A, Perez-Castillo A. Phosphodiesterase7 Inhibition Activates Adult Neurogensis in Hippocampus and Subventricular Zone In Vitro and In Vivo. Stem Cells. 2017 Feb;35(2):458-472. doi: 10.1002/stem.2480. Epub 2016 Sep 16. PMID: 27538853.

33: Celorrio M, Fernández-Suárez D, Rojo-Bustamante E, Echeverry-Alzate V, Ramírez MJ, Hillard CJ, López-Moreno JA, Maldonado R, Oyarzábal J, Franco R, Aymerich MS. Fatty acid amide hydrolase inhibition for the symptomatic relief of Parkinson’s disease. Brain Behav Immun. 2016 Oct;57:94-105. doi: 10.1016/j.bbi.2016.06.010. Epub 2016 Jun 16. PMID: 27318096.

32: Calleja-Conde J, Echeverry-Alzate V, Giné E, Bühler KM, Nadal R, Maldonado R, Rodríguez de Fonseca F, Gual A, López-Moreno JA. Nalmefene is effective at reducing alcohol seeking, treating alcohol-cocaine interactions and reducing alcohol-induced histone deacetylases gene expression in blood. Br J Pharmacol. 2016 Aug;173(16):2490-505. doi:  0.1111/bph.13526. Epub 2016 Jul 18. PMID: 27238566; PMCID: PMC4959953.

31: López-Moreno JA, Marcos M, Calleja-Conde J, Echeverry-Alzate V, Bühler KM, Costa-Alba P, Bernardo E, Laso FJ, Rodríguez de Fonseca F, Nadal R, Viveros MP, Maldonado R, Giné E. Histone Deacetylase Gene Expression Following Binge Alcohol Consumption in Rats and Humans. Alcohol Clin Exp Res. 2015 Oct;39(10):1939-50. doi: 10.1111/acer.12850. Epub 2015 Sep 13. PMID: 26365275.

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30: Martí-Prats L, Zornoza T, López-Moreno JA, Granero L, Polache A. Acetaldehyde sequestration by D-penicillamine prevents ethanol relapse-like drinking in rats: evidence from an operant self-administration paradigm. Psychopharmacology (Berl). 2015 Oct;232(19):3597-606. doi: 10.1007/s00213-015-4011-1. Epub 2015 Jul 9. PMID:  6153068.

29: Peñasco S, Mela V, López-Moreno JA, Viveros MP, Marco EM. Early maternal deprivation enhances voluntary alcohol intake induced by exposure to stressful events later in life. Neural Plast. 2015;2015:342761. doi: 10.1155/2015/342761. Epub 2015 Mar 2. PMID: 25821601; PMCID: PMC4363574.

28: Bühler KM, Giné E, Echeverry-Alzate V, Calleja-Conde J, de Fonseca FR, López-Moreno JA. Common single nucleotide variants underlying drug addiction: more than a decade of research. Addict Biol. 2015 Sep;20(5):845-71. doi: 10.1111/adb.12204. Epub 2015 Jan 21. PMID: 25603899.

27: Marco EM, Echeverry-Alzate V, López-Moreno JA, Giné E, Peñasco S, Viveros MP. Consequences of early life stress on the expression of endocannabinoid- related genes in the rat brain. Behav Pharmacol. 2014 Sep;25(5-6):547-56. doi: 10.1097/FBP.0000000000000068. PMID: 25083571.

26: Fernández-Fernández C, Callado LF, Girón R, Sánchez E, Erdozain AM, López-Moreno JA,, Morales P, Rodríguez de Fonseca F, Fernández-Ruiz J, Goya P, Meana JJ, Martín MI, Jagerovic N. Combining rimonabant and fentanyl in a single entity: preparation and pharmacological results. Drug Des Devel Ther. 2014 Feb 20;8:263-77. doi: 10.2147/DDDT.S55045. PMID: 24591816; PMCID: PMC3934591.

25: Echeverry-Alzate V, Giné E, Bühler KM, Calleja-Conde J, Olmos P, Gorriti MA, Nadal R, Rodríguez de Fonseca F, López-Moreno JA. Effects of topiramate on ethanol-cocaine interactions and DNA methyltransferase gene expression in the rat prefrontal cortex. Br J Pharmacol. 2014 Jun;171(12):3023-36. doi: 10.1111/bph.12636. PMID: 24527678; PMCID:  MC4055203.

24: Bühler KM, Huertas E, Echeverry-Alzate V, Giné E, Moltó E, Montoliu L, López-Moreno JA. Risky alcohol consumption in young people is associated with the fatty acid amide hydrolase gene polymorphism C385A and affective rating of drug pictures. Mol Genet Genomics. 2014 Jun;289(3):279-89. doi: 10.1007/s00438-013-0809-x. Epub 2014 Jan 10. PMID: 24407958.

23: López-Jiménez A, Walter NA, Giné E, Santos Á, Echeverry-Alzate V, Bühler KM, Olmos P, Giezendanner S, Moratalla R, Montoliu L, Buck KJ, López-Moreno JA. A spontaneous deletion of α-synuclein is associated with an increase in CB1 mRNA transcript and receptor expression in the hippocampus and amygdala: effects on alcohol consumption. Synapse. 2013 Jun;67(6):280-9. doi: 10.1002/syn.21639. Epub 2013 Mar 20. PMID: 23345080; PMCID: PMC3931467.

22: Giné E, Echeverry-Alzate V, López-Moreno JA, López-Jimenez A, Torres-Romero D, Perez-Castillo A, Santos A. Developmentally-induced hypothyroidism alters the expression of Egr-1 and Arc genes and the sensitivity to cannabinoid agonists in the hippocampus. Possible implications for memory and learning. Mol Cell Endocrinol. 2013 Jan 5;365(1):119-28. doi: 10.1016/j.mce.2012.10.004. Epub 2012 Oct 16. PMID: 23079472.

21: Echeverry-Alzate V, Tuda-Arízcun M, Bühler KM, Santos Á, Giné E, Olmos P, Gorriti MÁ, Huertas E, Rodríguez de Fonseca F, López-Moreno JA. Cocaine reverses the naltrexone-induced reduction in operant ethanol self-administration: the effects on immediate-early gene expression in the rat prefrontal cortex. Neuropharmacology. 2012 Nov;63(6):927-35. doi: 10.1016/j.neuropharm.2012.06.010. Epub 2012 Jun 28. PMID: 22749946.

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20: Huertas E, Bühler KM, Echeverry-Alzate V, Giménez T, López-Moreno JA. C957T polymorphism of the dopamine D2 receptor gene is associated with motor learning and heart rate. Genes Brain Behav. 2012 Aug;11(6):677-83. doi: 10.1111/j.1601-183X.2012.00793.x. Epub 2012 May 3. PMID: 22487365.

19: López-Moreno JA, Echeverry-Alzate V, Bühler KM. The genetic basis of the endocannabinoid system and drug addiction in humans. J Psychopharmacol. 2012 Jan;26(1):133-43. doi: 10.1177/0269881111416689. Epub 2011 Sep 21.  MID: 21937688.

18: Orio L, Crespo I, López-Moreno JA, Reyes-Cabello C, Rodríguez de Fonseca F, Gómez de Heras R. Additive effects of cannabinoid CB1 receptors blockade and cholecystokinin on feeding inhibition. Pharmacol Biochem Behav. 2011 Apr;98(2):220-6. doi: 10.1016/j.pbb.2010.12.007. Epub 2010 Dec 14. PMID: 21163296.

17: Zurita E, Chagoyen M, Cantero M, Alonso R, González-Neira A, López-Jiménez A, López-Moreno JA, Landel CP, Benítez J, Pazos F, Montoliu L. Genetic polymorphisms among C57BL/6 mouse inbred strains. Transgenic Res. 2011 Jun;20(3):481-9. doi: 10.1007/s11248-010-9403-8. Epub 2010 May 27. PMID: 20506040.

16: López-Moreno JA, López-Jiménez A, Gorriti MA, de Fonseca FR. Functional interactions between endogenous  annabinoid and opioid systems: focus on alcohol, genetics and drug-addicted behaviors. Curr Drug Targets. 2010 Apr;11(4):406-28. doi: 10.2174/138945010790980312. PMID: 20196742.

15: Alén F, Mouret A, Viveros MP, Llorente R, Lepousez G, Lledo PM, López-Moreno JA. Converging action of alcohol consumption and cannabinoid receptor activation on adult hippocampal neurogenesis. Int J Neuropsychopharmacol. 2010 Mar;13(2):191-205. doi: 10.1017/S1461145709991118. Epub 2010 Jan 5. PMID: 20047713.

14: Peraile I, Torres E, Mayado A, Izco M, Lopez-Jimenez A, López-Moreno JA, Colado MI, O’Shea E. Dopamine transporter down-regulation following repeated cocaine: implications for 3,4-methylenedioxymethamphetamine-induced acute effects and long-term neurotoxicity in mice. Br J Pharmacol. 2010 Jan;159(1):201-11. doi: 10.1111/j.1476- 81.2009.00522.x. Epub 2009 Dec 10. PMID: 20015297; PMCID: PMC2823365.

13: Alén F, Gómez R, González-Cuevas G, Navarro M, López-Moreno JA. Nicotine causes opposite effects on alcohol intake: Evidence in an animal experimental model of abstinence and relapse from alcohol. Nicotine Tob Res. 2009 Nov;11(11):1304-11. doi: 10.1093/ntr/ntp139. Epub 2009 Sep 30. PMID: 19793787.

12: Moreno-Sanz G, O’Shea E, Orio L, Escobedo I, González-Cuevas G, Navarro M, Colado MI, López-Moreno JA. Administration of MDMA to ethanol-deprived rats increases ethanol operant self-administration and dopamine release during reinstatement. Int J Neuropsychopharmacol. 2009 Aug;12(7):929-40. doi: 10.1017/S1461145709009912. Epub 2009 Feb 23. PMID: 19236733.

11: Alén F, Santos A, Moreno-Sanz G, González-Cuevas G, Giné E, Franco-Ruiz L, Navarro M, López-Moreno JA. Cannabinoid-induced increase in relapse-like drinking is prevented by the blockade of the glycine-binding site of N-methyl-D- aspartate receptors. Neuroscience. 2009 Jan 23;158(2):465-73. doi: 10.1016/j.neuroscience.2008.10.002. Epub 2008 Oct 10. PMID: 18977415.

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10: Alen F, Moreno-Sanz G, Isabel de Tena A, Brooks RD, López-Jimenez A, Navarro M, López-Moreno JA. Pharmacological activation of CB1 and D2 receptors in rats: predominant role of CB1 in the increase of alcohol relapse. Eur J Neurosci. 2008 Jun;27(12):3292-8. doi: 10.1111/j.1460-9568.2008.06302.x. Epub 2008 Jun 1. PMID: 18554293.

9: López-Moreno JA, González-Cuevas G, Moreno G, Navarro M. The pharmacology of the endocannabinoid system: functional and structural interactions with other neurotransmitter systems and their repercussions in behavioral addiction. Addict Biol. 2008 Jun;13(2):160-87. doi: 10.1111/j.1369-1600.2008.00105.x. Epub 2008 Apr 16. PMID: 18422831.

8: López-Moreno JA, Scherma M, Rodríguez de Fonseca F, González-Cuevas G, Fratta W, Navarro M. Changed accumbal responsiveness to alcohol in rats pre- treated with nicotine or the cannabinoid receptor agonist WIN 55,212-2. Neurosci Lett. 2008 Mar 5;433(1):1-5. doi: 10.1016/j.neulet.2007.11.074. Epub 2007 Dec 23. PMID: 18261849.

7: Asúa T, Bilbao A, Gorriti MA, López-Moreno JA, Del Mar Alvarez M, Navarro M, Rodríguez de Fonseca F, Perez-Castillo A, Santos A. Implication of the endocannabinoid system in the locomotor hyperactivity associated with congenital hypothyroidism. Endocrinology. 2008 May;149(5):2657-66. doi: 10.1210/en.2007-1586. Epub 2008 Jan 24. PMID: 18218697.

6: González-Cuevas G, Aujla H, Martin-Fardon R, López-Moreno JA, Navarro M, Weiss F. Subchronic cannabinoid agonist (WIN 55,212-2) treatment during cocaine abstinence alters subsequent cocaine seeking behavior.                             Neuropsychopharmacology. 2007 Nov;32(11):2260-6. doi: 10.1038/sj.npp.1301365. Epub 2007 Mar 28. PMID: 17392740.

5: Rabadán Díaz JV, López-Moreno JA,, Soria Quiles A, Del Pino Moreno AL. Déficit neurológico en el postoperatorio de una cesárea realizada con anestesia intradural tras un brote de esclerosis múltiple no diagnosticada [Neurological deficit during recovery from cesarean section under spinal anesthesia after the appearance of undiagnosed multiple sclerosis]. Rev Esp Anestesiol Reanim. 2006 Dec;53(10):673-4. Spanish. PMID: 17302088.

4: López-Moreno JA, González-Cuevas G, Navarro M. The CB1 cannabinoid receptor antagonist rimonabant chronically prevents the nicotine-induced relapse to alcohol. Neurobiol Dis. 2007 Feb;25(2):274-83. doi: 10.1016/j.nbd.2006.09.010. Epub 2006 Oct 24. PMID: 17067804.

3: Moreno M, López-Moreno JA,, Rodríguez de Fonseca F, Navarro M. Behavioural effects of quinpirole following withdrawal of chronic treatment with the CB1 agonist, HU-210, in rats. Behav Pharmacol. 2005 Sep;16(5-6):441-6. doi: 10.1097/00008877-200509000-00017. PMID: 16148449.

2: López-Moreno JA, Trigo-Díaz JM, Rodríguez de Fonseca F, González Cuevas G, Gómez de Heras R, Crespo Galán I, Navarro M. Nicotine in alcohol deprivation increases alcohol operant self-administration during reinstatement. Neuropharmacology. 2004 Dec;47(7):1036-44. doi: 10.1016/j.neuropharm.2004.08.002. PMID: 15555637.

1: López-Moreno JA, González-Cuevas G, Rodríguez de Fonseca F, Navarro M. Long- lasting increase of alcohol relapse by the cannabinoid receptor agonist WIN 55,212-2 during alcohol deprivation. J Neurosci. 2004 Sep 22;24(38):8245-52. doi: 10.1523/JNEUROSCI.2179-04.2004. PMID: 15385608; PMCID: PMC6729684.